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It is reported that LC increases GnRH secretion from the hypothalamus by acting on the HPG axis [16, 17] and causing K + -induced depolarization in hypothalamic neuronal cells to increase its secretory activity [80, 81]
Unfavorable environmental causes overproduction of ROS that leads to considerable changes in cellular lipid membrane causing peroxidation of lipids (shown by increased MDA) 52
Su H, Lang B, Newman E
PMID: 33493036 Packer M et al (2021): Effect of Empagliflozin on Worsening Heart Failure Events in Patients With Heart Failure and Preserved Ejection Fraction: EMPEROR-Preserved Trial
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